Selective loss of Mycobacterium leprae responsiveness of circulating lymphocytes in primary neuritic leprosy.
نویسندگان
چکیده
منابع مشابه
Use of 18 and 36 kDa antigens of Mycobacterium Leprae for detection of this microorganism in Iranian Leprosy patients by PCR
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BACKGROUND Leprosy is a chronic infectious disease caused by Mycobacterium leprae which is an obligate intracellular pathogen. It is characterised by a broad spectrum of clinical forms dictated by the patient's immune response to the organism. The tuberculoid pole has good cell mediated immunity to M. leprae, with few lesions and bacilli while the lepromatous pole has poor immunity coupled with...
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Split anergy represented by delayed-type hypersensitivity skin reaction to tuberculin, but not to leprosin, is known to occur in a distinct proportion of leprosy patients. The mechanism was originally attributed to Mycobacterium leprae-specific suppression of T cells toward common mycobacterial antigens. This study ascertained an alternative explanation, attributing the phenomenon to selective ...
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In order to understand the mechanism of unresponsiveness towards Mycobacterium leprae antigens in leprosy, we evaluated the role of M. leprae sonicate antigens in regulating the expression of the costimulatory molecules B7-1, CD28, intercellular adhesion molecule-1 (ICAM-1), LFA-1alpha, LFA-1beta and Mac-1 on the lymphocytes of both leprosy patients and healthy subjects. It was observed that th...
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عنوان ژورنال:
- Leprosy review
دوره 52 1 شماره
صفحات -
تاریخ انتشار 1981